Define the lamina propria.
The mottling of the cytoplasm of the parietal cell reflects the intracellular canalicular system in that cell that greatly increases the surface area for the secretion of HCl by that cell type. This is a medium power view of the cell population one would find in the isthmus and neck of a gastric oxyntic gland. Where are the connective tissue fibers and cells of the lamina propria?
A population of stem cells would also be found in the neck of the gastric glands, but are difficult to appreciate in the absence of mitotic figures.
Identify gastric pits and gastric glands.
The parietal cells are the source of both hydrochloric acid HCl and gastric intrinsic factor. Note that the simple columnar mucin-secreting cells of the stomach surface continue down into the open pits or foveolae of the glands for just a short distance.
In this image, appreciate the change in cell type as one moves from the neck of the gland towards the base of the gastric gland. Many blood vessels run in the submucosa. The parts of gastric glands are isthmus, neck , and base. Both mucous neck cells an additional source of mucus for the stomach and the large, eosinophilic parietal oxyntic cells can be seen.
Note the abundant mucigen granules found in the cytoplasm of all of these cells. Identify the mucosa, submucosa, muscularis externa and serosa.
A parietal cell is also seen in this image for comparison. Is the outermost layer an adventitia or serosa?
Note also the very sparse lamina propria. The four layers typical of the GI tract can be defined: Notice that the submucosa extends up into the temporary folds or rugae which protrude into the lumen of the stomach.
Where is the muscularis mucosae in relation to the glands?